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Clorazepate dipotassium (brand names: Tranxene-SD®, Gen-Xene®) is a benzodiazepine used to treat behavior disorders and seizures. Anxiety disorders and phobias are most often treated with this medication.
It is used off label (extra label) to treat seizures and behavior disorders in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.
If you miss a dose, give it as soon as you remember, and then wait the recommended time as prescribed by your veterinarian for the next dose. Do not give the pet two doses at once.
Side effects of clorazepate dipotassium may include:
Serious adverse reactions may occur. If any of the following signs develop, stop giving clorazepate dipotassium and contact your veterinarian immediately:
This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.
DO NOT USE clorazepate dipotassium in pets that:
USE WITH EXTREME CAUTION in pets that:
When using clorazepate dipotassium long-term, do not stop abruptly, as it can cause seizures.
The following medications should be used with caution when given with clorazepate dipotassium:
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Mar 19, 2025.
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